Wednesday, August 12, 2026

Lion Nebula Roars to Life With NASA’s Webb - UNIVERSE

Observing across the starry “plains” of space, NASA’s James Webb Space Telescope has taken new images of NGC 2392, nicknamed the Lion Nebula. NASA’s Hubble Space Telescope previously viewed this planetary nebula in 2000, imaging the lion face-shaped target in visible light and revealing features such as the “mane” of hazy, comet-shaped objects. Now Webb has captured a clearer, more detailed view of the Lion Nebula due to its high-resolution imaging.

Lion Nebula (NIRCam and MIRI Image)

At first glance the nebula’s overall structure in Webb’s infrared images, with both the NIRCam (Near Infrared Camera) and MIRI (Mid Infrared Instrument) instruments, may look quite similar to Hubble’s earlier visible-light view. However, Webb’s infrared vision highlights features like compact clumps of dust and a haze of ionized gas. It’s taken several thousand years for this collection of gas and dust to reach its current shape, and the nebula’s components continue to be altered.

The source of these constant changes and the reason for the Lion Nebula’s distinct appearance is located at the center: the remains of a dying star. Though it looks like the button nose of the lion, its energy and radiation are powering the intricate structures seen here.

Lion Nebula (MIRI Image)

NASA’s James Webb Space Telescope’s mid-infrared image of planetary nebula NGC 2392, nicknamed the Lion Nebula, highlights the varying dust structures. Some dust is being destroyed by the dying central star’s radiation, while some dust filaments manage to survive.

Image: NASA, ESA, CSA, STScI; Image Processing: Alyssa Pagan (STScI)

Massive stars undergo supernova explosions at the end of their lives, but these kinds of events are few and far in between. Most of the universe’s stars have lower masses, like the one belonging to NGC 2392. When a lower-mass star can no longer sustain itself with nuclear reactions in its core, the star becomes unstable and pulsates, losing its mass by shedding its outer layers, which then turn into shells of gas and dust called a planetary nebula. (Stars at this life stage are responsible for producing much of the universe’s observable dust.) The star’s radiation drives the ejected material away, leaving behind the very hot stellar core, also known as a white dwarf.

In the Lion Nebula’s case, the death of the oxygen-rich central star has left behind a white dwarf that is “cooking” everything from the inside and producing a bubble of ionized gas as it does. The gas bubble, which forms the lion’s face, is expanding over time and destroying dust that is in its path. Understanding why the swept-up gas has a complex structure of rings and shells, a common feature in planetary nebulae, is an ongoing endeavor.

The mane of the lion is the interior of a dust shell that is being illuminated by the white dwarf at the center. The tufts of hair, which look like cometary tails of material, are compact clumps of dust that have survived the stellar core’s radiation and protect the material that lies behind them.

Webb’s imagery “freezes” this planetary nebula in time, though the star’s death, and its tumultuous effects, go on. NGC 2392 will continue to undergo changes as its gas and dust migrate away from the stellar core. Astronomers estimate the lion will eventually disperse in approximately 10,000 years — a relatively short period in astronomical terms.

The James Webb Space Telescope is the world’s premier space science observatory. Webb is solving mysteries in our solar system, looking beyond to distant worlds around other stars, and probing the mysterious structures and origins of our universe and our place in it. Webb is an international program led by NASA with its partners, ESA (European Space Agency) and CSA (Canadian Space Agency).

To learn more about Webb, visit: https://science.nasa.gov/webb 

Source: Lion Nebula Roars to Life With NASA’s Webb - NASA Science

Cancer Might Be Breaking Its Own DNA, And That Could Be Its Weak Spot

To grow as fast as they do, cancer cells push certain genes to work far harder than any healthy cell would tolerate. A new study in Science Advances suggests that this relentless overdrive doesn’t just fuel growth, it may also be quietly damaging the tumor’s own DNA, in a way that could eventually be turned against it.

The study, led by PhD student Osama Hidmi under Prof. Rami Aqeilan at the Hebrew University of Jerusalem, points to a specific culprit: super-enhancers, the powerful DNA control regions that act like control panels, cranking up the activity of nearby cancer-promoting genes.

Growing fast has a cost

Cancer cells activate growth, survival, and division genes at levels healthy cells never reach. That level of activity is known as hypertranscription, and it turns out to place real physical strain on the DNA itself. Using a genome-mapping technique called sBLISS, the researchers charted exactly where double-strand breaks, the most severe form of DNA damage, in which both strands of the molecule are severed, occur across the cancer genome.

The breaks weren’t scattered randomly. They clustered inside the genes that super-enhancers were driving hardest, suggesting that keeping a gene locked in constant high-output mode is enough, on its own, to make the DNA snap.

A repair cycle that isn’t perfect

Cancer cells aren’t defenseless against this damage, they repair it, repeatedly, using the cell’s natural DNA-repair machinery. But repair isn’t the same as restoration. Each cycle of breaking and fixing carries a small risk of error, and over time those errors accumulate specifically in the regions under the most transcriptional stress.

“That cycle may help tumors survive in the short term, but it also increases the risk of mutations that can fuel cancer’s evolution,” says Prof. Rami Aqeilan.

In other words, the very regions cancer relies on most to keep growing are also becoming increasingly unstable, a self-inflicted mutation engine that could help tumors adapt, resist treatment, or spread.

Turning a dependency into a target

The flip side of this finding is what makes it interesting for treatment. Because cancer cells depend so heavily on super-enhancer-driven genes to keep growing, those same DNA regions may represent a genuine vulnerability. Therapies designed to interfere with either the intense gene activity itself, or with the repair machinery patching up the resulting breaks, could make it much harder for tumors to keep evolving.

As Hidmi put it, the fact that cancer cells depend on these high-stress regions to survive means they may also be unusually vulnerable there, opening the door to treatments that target the very processes tumors need most.

Original paper: Hidmi, O., Shatleh, D., Oster Flayshman, S., Monin, J., & Aqeilan, R. I. (2026). Superenhancers shape the landscape and repair dynamics of transcription-associated DNA breaks in cancer. Science Advances, 12(4). https://www.science.org/doi/10.1126/sciadv.aeb6379 

Source: Cancer Might Be Breaking Its Own DNA, And That Could Be Its Weak Spot