.jpg)
World’s first pelvis
transplant carried out in Italy
The Centre for Orthopaedic Trauma (CTO) in Turin, Italy, has performed the
world’s first pelvis transplant, an operation that saved the life of an
18-year-old suffering from osteosarcoma. The condition was considered
inoperable and the boy responded quite well to 16 cycles of chemotherapy but
the doctors didn’t stop at the traditional treatment, racking their brains to
find a definitive solution.
Osteosarcoma is a cancerous tumor in a bone. Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchymal origin (and thus a sarcoma) and that exhibits osteoblastic differentiation and produces malignantosteoid. Osteosarcoma is the most common histological form of primary bone cancer and it is most prevalent in children and young adults. It tend to occur at the sites of bone growth, presumably because proliferation makes osteoblastic cells in this region prone to acquire mutations that could lead to transformation of cells (RB gene and p53 gene are commonly involved).
They therefore had half a titanium pelvis built in the US and had it coated with tantalum, a material that is fully compatible with human bones, made to measure from a cast taken from the patient’s CT scan. The operation, which lasted about 12 hours, involved removing the right-hand side of the pelvis and hip affected by the tumour and replacing them with the prosthesis. The operation was a great success for Italy.
Reference:
http://www.cittadellasalute.to.it/index.php?option=com_content&view=article&id=6721:per-la-prima-volta-al-mondo-salvato-paziente-oncologico-con-trapianto-di-bacino-in-titanio-presso-lospedale-cto-di-torino&catid=364:comunicati-stampa-anno-2015&Itemid=71
Osteosarcoma is a cancerous tumor in a bone. Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchymal origin (and thus a sarcoma) and that exhibits osteoblastic differentiation and produces malignantosteoid. Osteosarcoma is the most common histological form of primary bone cancer and it is most prevalent in children and young adults. It tend to occur at the sites of bone growth, presumably because proliferation makes osteoblastic cells in this region prone to acquire mutations that could lead to transformation of cells (RB gene and p53 gene are commonly involved).
They therefore had half a titanium pelvis built in the US and had it coated with tantalum, a material that is fully compatible with human bones, made to measure from a cast taken from the patient’s CT scan. The operation, which lasted about 12 hours, involved removing the right-hand side of the pelvis and hip affected by the tumour and replacing them with the prosthesis. The operation was a great success for Italy.
Reference:
http://www.cittadellasalute.to.it/index.php?option=com_content&view=article&id=6721:per-la-prima-volta-al-mondo-salvato-paziente-oncologico-con-trapianto-di-bacino-in-titanio-presso-lospedale-cto-di-torino&catid=364:comunicati-stampa-anno-2015&Itemid=71
corina marinescu
No comments:
Post a Comment