Researchers at the Medical College of Georgia at Augusta University have found that the TIP peptide, a synthetic version of the tip of the cancer-killing immune molecule tumor necorsis factor, may strengthen the barrier created by sodium channels in the cells that line capillaries in our lungs. Strengthening this barrier may prevent worsening pneumonia.
“We showed that these channels are present in human capillary endothelial cells and that these channels play a really important role in protecting us from pneumolysin,” says Dr. Rudolf Lucas, vascular biologist at the Vascular Biology Center at the Medical College of Georgia at Augusta University and the study’s corresponding author.
“We also provided more evidence that targeting these channels with the TIP peptide or something similar is a solid strategy for reducing dangerous fluid volume in your lungs,” says Lucas. The studies were conducted in the endothelial cells that line human lung capillaries, known to form a tight barrier for the blood vessels.
Source:http://jagwire.augusta.edu/archives/47212
Source: Corina Marinescu
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