Saturday, November 18, 2017
Immortalized human skin cells (HaCaT keratinocytes) expressing fluorescently tagged keratin - MEDICINE
Dr. Bram van den Broek reveals an exceptional and microscopic view of something we see every day — our skin. The image depicts a cell expressing an excessive amount of keratin, seen here fluorescently labeled in yellow.
Keratin is an important structural protein in skin cells. The keratin fibrous network protects the cells against mechanical stress, and is involved in many other cellular functions, like cell migration and adhesion. Studying the structure, dynamics and regulation of the keratin network can reveal information about such processes. In certain types of cancer, for instance, reduced amounts of specific keratins are indicative for tumor aggressiveness.
This photo won 1st Place
2017 Photomicrography Competition
Credits: Dr. Bram van den Broek, Andriy Volkov, Dr. Kees Jalink, Dr. Reinhard Windoffer & Dr. Nicole Schwarz
The Netherlands Cancer Institute
BioImaging Facility & Department of Cell Biology
Amsterdam, The Netherlands
Magnification40x (objective lens magnification)
Source: Corina Marinescu