Saturday, December 31, 2016
From start to finish this series has kept me captivated. I continuously check back to see if there is a new book in the series. I couldn't put it down!
Hell really is other people…
Alec von Hornet has somehow endured the agony of being half-eaten and installed as a living-objet d’art in a depraved woman’s estate. Barely sane, he’s rescued and healed in a painful procedure that leaves him whole, but oddly vulnerable. Recovered and rehabilitated by the same warrior monks who rescued Alec, his beloved Alexa is determined to win him back. As their paths converge, they find the way blocked by family, traitors, pirates, and a deranged general with an inexplicable connection to Alec. But the lovers are determined to reunite, come what may—even if it means destroying half the Universe in the process.
Researchers at the University of Cincinnati (UC) College of Medicine have been able to generate multifunctional RNA nanoparticles that could overcome treatment resistance in breast cancer, potentially making existing treatments more effective in these patients.
The study, published in the Dec. 14, 2016, online edition of American Chemical Society’s ACS Nano and led by Xiaoting Zhang, PhD, associate professor in the Department of Cancer Biology at the UC College of Medicine, shows that using a nanodelivery system to target HER2-positive breast cancer and stop production of the protein MED1 could slow tumor growth, stop cancer from spreading and sensitize the cancer cells to treatment with tamoxifen, a known therapy for estrogen-driven cancer.
MED1 is a protein often produced at abnormally high levels in breast cancer cells that when eliminated is found to stop cancer cell growth. HER2-positive breast cancer involves amplification of a gene encoding, or programming, the protein known as human epidermal growth factor receptor 2, which also promotes the growth of cancer cells. MED1 co-produces (co-expresses) and co-amplifies with HER2 in most cases, and Zhang’s previous studies have shown their interaction plays key roles in anti-estrogen treatment resistance.
Looking out the window of an airplane, you might be lucky enough to see "the glory" in the direction directly opposite the Sun. Before airplanes, the phenomenon, known to some as the heiligenschein or the Specter of the Brocken, was sometimes seen from mountaintops. There, when conditions were right, one could look away from the Sun and see what appeared to be the shadow of a giant surrounded by a bright halo.
The giant turns out to be the observer, as in the modern version a silhouette of an plane frequently occupies the glory's center. This bright glory was photographed two weeks ago over Michigan from an airplane on approach to O'Hare International Airport. The cause of the glory is still being researched and is relatively complex.
Surely, small droplets of water in some way reflect, refract, and diffract sunlight backwards towards the Sun. The phenomenon has similar counterparts in other branches of science including astronomy, where looking out from the Earth in the direction opposite the Sun yields a bright spot called the gegenschein.
Image & info via APODhttps://apod.nasa.gov/apod/astropix.html
Image Credit & Copyright: Shane Larson (Adler Planetarium, CIERA-Northwestern)