Friday, January 3, 2025

Grand Spiral NGC 5643 - UNIVERSE

Viewed face-on, grand spiral galaxy NGC 5643 has a festive appearance in this colorful cosmic portrait. Some 55 million light-years distant, the galaxy extends for over 100,000 light-years, seen within the boundaries of the southern constellation Lupus. Its inner 40,000 light-years are shown in sharp detail in this composite of Hubble Space Telescope image data. The galaxy’s magnificent spiral arms wind from a yellowish central region dominated by light from old stars, while the spiral arms themselves are traced by dust lanes, young blue stars and reddish star forming regions. The bright compact core of NGC 5643 is also known as a strong emitter of radio waves and X-rays. In fact, NGC 5643 is one of the closest examples of the Seyfert class of active galaxies, where vast amounts of dust and gas are thought to be falling into a central massive black hole.


Image & info via APOD
Image Credit: 
ESA / Hubble & NASA
 

Source: Grand Spiral NGC 5643 – Scents of Science  

 

Brain cells remain healthy after a month on the International Space Station, but mature faster than brain cells on Earth

Microgravity is known to alter the muscles, bones, the immune system and cogni­tion, but little is known about its specific impact on the brain. To discover how brain cells respond to microgravity, Scripps Research scientists, in collaboration with the New York Stem Cell Foundation, sent tiny clumps of stem-cell derived brain cells called “organoids” to the International Space Station (ISS).

Surprisingly, the organoids were still healthy when they returned from orbit a month later, but the cells had matured faster compared to identical organoids grown on Earth—they were closer to becoming adult neurons and were beginning to show signs of specialization. The results, which could shed light on potential neurological effects of space travel, were published on October 23, 2024, in Stem Cells Translational Medicine.


“The fact that these cells survived in space was a big surprise,” says co-senior author Jeanne Loring, PhD, professor emeritus in the Department of Molecular Medicine and founding director of the Center for Regenerative Medicine at Scripps Research. “This lays the groundwork for future experiments in space, in which we can include other parts of the brain that are affected by neurodegenerative disease.”

On Earth, the team used stem cells to create organoids consisting of either cortical or dopaminergic neurons, which are the neuronal populations impacted in multiple sclerosis and Parkinson’s disease—diseases that Loring has studied for decades. Some organoids also included microglia, a type of immune cell that is resident within the brain, to examine the impact of microgravity on inflammation.

Organoids are usually grown in a nutrient-rich liquid medium that must be changed regularly to ensure that the cells have adequate nutrition, and to remove waste products. To avoid the need for lab work on the ISS, the team pioneered a method for growing smaller-than-usual organoids in cryovials—small, airtight vials that were originally designed for deep freezing.

The organoids were prepared in labs at the Kennedy Space Station and traveled to the ISS in a miniature incubator. After a month in orbit, they returned to Earth, where the team showed that they were healthy and intact.

To examine how the space environment impacts cellular functions, the team compared the cells’ RNA expression patterns—a measure of gene activity—to identical “ground control” organoids that had remained on Earth. Surprisingly, they found that the organoids grown in microgravity had higher levels of genes associated with maturity and lower levels of genes associated with proliferation compared to the ground controls, meaning that the cells exposed to microgravity developed faster and replicated less than those on Earth.

“We discovered that in both types of organoids, the gene expression profile was characteristic of an older stage of development than the ones that were on ground,” says Loring. “In microgravity, they developed faster, but it’s really important to know these were not adult neurons, so this doesn’t tell us anything about aging.”

The team also noted that, contrary to their hypothesis, there was less inflammation and lower expression of stress-related genes in organoids grown in microgravity, but more research is needed to determine why.

Loring speculates that microgravity conditions may more closely mirror the conditions experienced by cells within the brain compared to organoids grown under conventional lab conditions and in the presence of gravity.

“The characteristics of microgravity are probably also at work in people’s brains, because there’s no convection in microgravity—in other words, things don’t move,” says Loring. “I think that in space, these organoids are more like the brain because they’re not getting flushed with a whole bunch of culture medium or oxygen. They’re very independent; they form something like a brainlet, a microcosm of the brain.”

The paper describes the team’s first space mission, but since then, they have sent four more missions to the ISS. With each one, they’ve replicated the conditions from the first mission and added additional experiments.

 “The next thing we plan to do is to study the part of the brain that’s most affected by Alzheimer’s disease,” says Loring. “We also want to know whether there are differences in the way neurons connect with each other in space. With these kinds of studies, you can’t rely on earlier work to predict what the result would be because there is no earlier work. We’re on the ground floor, so to speak; in the sky, but on the ground floor.”

Source: https://www.scripps.edu/news-and-events/press-room/2024/20241216-loring-stem-cells.html

Journal article: https://academic.oup.com/stcltm/article/13/12/1186/7833382

Image: Brain organoids were healthy and continued to grow after spending a month on the International Space Station. (Credit: Jeanne Loring 

Source: Brain cells remain healthy after a month on the International Space Station, but mature faster than brain cells on Earth – Scents of Science  

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Thursday, January 2, 2025

Ice Clouds over a Red Planet - UNIVERSE

If you could stand on Mars — what might you see? You might look out over a vast orange landscape covered with rocks under a dusty orange sky, with a blue-tinted Sun setting over the horizon, and odd-shaped water clouds hovering high overhead. This was just the view captured last March by NASA’s rolling explorer, Perseverance. The orange coloring is caused by rusted iron in the Martian dirt, some of which is small enough to be swept up by winds into the atmosphere. The blue tint near the setting Sun is caused by blue light being preferentially scattered out from the Sun by the floating dust. The light-colored clouds on the right are likely composed of water-ice and appear high in the Martian atmosphere. The shapes of some of these clouds are unusual for Earth and remain a topic of research.


Image & info via APOD
Image Credit: 
NASAJPL-CaltechKevin M. Gill; Processing: Rogelio Bernal Andreo
  

Source: Ice Clouds over a Red Planet – Scents of Science  

 

New Research Identifies Key Cellular Mechanism Driving Alzheimer’s Disease

NEW YORK, NY, December 23, 2024 — Researchers with the CUNY ASRC have unveiled a critical mechanism that links cellular stress in the brain to the progression of Alzheimer’s disease (AD). The study, published in the journal Neuron, highlights microglia, the brain’s primary immune cells, as central players in both the protective and harmful responses associated with the disease.


Microglia, often dubbed the brain’s first responders, are now recognized as a significant causal cell type in Alzheimer’s pathology. However, these cells play a double-edged role: some protect brain health, while others worsen neurodegeneration. Understanding the functional differences between these microglial populations has been a research focus for Pinar Ayata, the study’s principal investigator and a professor with the CUNY ASRC Neuroscience Initiative and the CUNY Graduate Center’s Biology and Biochemistry programs.


“We set out to answer what are the harmful microglia in Alzheimer’s disease and how can we therapeutically target them,” said Ayata. “We pinpointed a novel neurodegenerative microglia phenotype in Alzheimer’s disease characterized by a stress-related signaling pathway.”

The research team discovered that activation of this stress pathway, known as the integrated stress response (ISR), prompts microglia to produce and release toxic lipids. These lipids damage neurons and oligodendrocyte progenitor cells—two cell types essential for brain function and most impacted in Alzheimer’s disease. Blocking this stress response or the lipid synthesis pathway reversed symptoms of Alzheimer’s disease in preclinical models.

Electron micrographs show typical microglia in the prefrontal cortex of a 92-year-old healthy female (left) and dark microglia a 91-year-old female patient with Alzheimer’s disease (right).

Key Findings

·         Dark Microglia and Alzheimer’s Disease: Using electron microscopy, the researchers identified an accumulation of “dark microglia,” a subset of microglia associated with cellular stress and neurodegeneration, in postmortem brain tissues from Alzheimer’s patients. These cells were present at twice the levels seen in healthy-aged individuals.

·         Toxic Lipid Secretion: The ISR pathway in microglia was shown to drive the synthesis and release of harmful lipids that contribute to synapse loss, a hallmark of Alzheimer’s disease.

·         Therapeutic Potential: In mouse models, inhibiting ISR activation or lipid synthesis prevented synapse loss and accumulation of neurodegenerative tau proteins, offering a promising pathway for therapeutic intervention.

“These findings reveal a critical link between cellular stress and the neurotoxic effects of microglia in Alzheimer’s disease,” said the study’s co-lead author Anna Flury, a member of Ayata’s lab and a Ph.D. student with the CUNY Graduate Center’s Biology Program. “Targeting this pathway may open up new avenues for treatment by either halting the toxic lipid production or preventing the activation of harmful microglial phenotypes.”

Implications for Alzheimer’s Patients
This research underscores the potential of developing drugs that target specific microglial populations or their stress-induced mechanisms. “Such treatments could significantly slow or even reverse the progression of Alzheimer’s disease, offering hope to millions of patients and their families,” explained co-lead author Leen Aljayousi, a member of Ayata’s lab and a Ph.D. student with the CUNY Graduate Center’s Biology Program.

The study represents a major leap forward in understanding the cellular underpinnings of Alzheimer’s and emphasizes the importance of microglial health in maintaining overall brain function.

Source: https://asrc.gc.cuny.edu/headlines/2024/12/new-research-identifies-key-cellular-mechanism-driving-alzheimers-disease/

Source: New Research Identifies Key Cellular Mechanism Driving Alzheimer’s Disease – Scents of Science

Dark energy ‘doesn’t exist’ so can’t be pushing ‘lumpy’ Universe apart – study

One of the biggest mysteries in science – dark energy – doesn’t actually exist, according to researchers looking to solve the riddle of how the Universe is expanding.

For the past 100 years, physicists have generally assumed that the cosmos is growing equally in all directions. They employed the concept of dark energy as a placeholder to explain unknown physics they couldn’t understand, but the contentious theory has always had its problems.

Now a team of physicists and astronomers at the University of Canterbury in Christchurch, New Zealand are challenging the status quo, using improved analysis of supernovae light curves to show that the Universe is expanding in a more varied, “lumpier” way.

The new evidence supports the “timescape” model of cosmic expansion, which doesn’t have a need for dark energy because the differences in stretching light aren’t the result of an accelerating Universe but instead a consequence of how we calibrate time and distance.

It takes into account that gravity slows time, so an ideal clock in empty space ticks faster than inside a galaxy.

The model suggests that a clock in the Milky Way would be about 35 per cent slower than the same one at an average position in large cosmic voids, meaning billions more years would have passed in voids. This would in turn allow more expansion of space, making it seem like the expansion is getting faster when such vast empty voids grow to dominate the Universe.

Professor David Wiltshire, who led the study, said: “Our findings show that we do not need dark energy to explain why the Universe appears to expand at an accelerating rate.

“Dark energy is a misidentification of variations in the kinetic energy of expansion, which is not uniform in a Universe as lumpy as the one we actually live in.”

He added: “The research provides compelling evidence that may resolve some of the key questions around the quirks of our expanding cosmos.

“With new data, the Universe’s biggest mystery could be settled by the end of the decade.”

The new analysis has been published in the journal Monthly Notices of the Royal Astronomical Society Letters.

Dark energy is commonly thought to be a weak anti-gravity force which acts independently of matter and makes up around two thirds of the mass-energy density of the Universe.

The standard Lambda Cold Dark Matter (ΛCDM) model of the Universe requires dark energy to explain the observed acceleration in the rate at which the cosmos is expanding.

Scientists base this conclusion on measurements of the distances to supernova explosions in distant galaxies, which appear to be farther away than they should be if the Universe’s expansion were not accelerating.

However, the present expansion rate of the Universe is increasingly being challenged by new observations.

Firstly, evidence from the afterglow of the Big Bang – known as the Cosmic Microwave Background (CMB) – shows the expansion of the early Universe is at odds with current expansion, an anomaly known as the “Hubble tension”.

In addition, recent analysis of new high precision data by the Dark Energy Spectroscopic Instrument (DESI) has found that the ΛCDM model does not fit as well as models in which dark energy is evolving over time, rather than remaining constant.

Both the Hubble tension and the surprises revealed by DESI are difficult to resolve in models which use a simplified 100-year-old cosmic expansion law – Friedmann’s equation.

This assumes that, on average, the Universe expands uniformly – as if all cosmic structures could be put through a blender to make a featureless soup, with no complicating structure. However, the present Universe actually contains a complex cosmic web of galaxy clusters in sheets and filaments that surround and thread vast empty voids.

Professor Wiltshire added: “We now have so much data that in the 21st century we can finally answer the question – how and why does a simple average expansion law emerge from complexity?

“A simple expansion law consistent with Einstein’s general relativity does not have to obey Friedmann’s equation.”

The researchers say that the European Space Agency’s Euclid satellite, which was launched in July 2023, has the power to test and distinguish the Friedmann equation from the timescape alternative. However, this will require at least 1,000 independent high quality supernovae observations.

When the proposed timescape model was last tested in 2017 the analysis suggested it was only a slightly better fit than the ΛCDM as an explanation for cosmic expansion, so the Christchurch team worked closely with the Pantheon+ collaboration team who had painstakingly produced a catalogue of 1,535 distinct supernovae.

They say the new data now provides “very strong evidence” for timescape. It may also point to a compelling resolution of the Hubble tension and other anomalies related to the expansion of the Universe.

Further observations from Euclid and the Nancy Grace Roman Space Telescope are needed to bolster support for the timescape model, the researchers say, with the race now on to use this wealth of new data to reveal the true nature of cosmic expansion and dark energy.

Source: https://ras.ac.uk/news-and-press/research-highlights/dark-energy-doesnt-exist-so-cant-be-pushing-lumpy-universe-apart 

Source: Dark energy ‘doesn’t exist’ so can’t be pushing ‘lumpy’ Universe apart – study – Scents of Science 

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