Young Stars in Their Baby Blanket of Dust - UNIVERSE

Newborn stars peek out from beneath their natal blanket of dust in this dynamic image of the Rho Ophiuchi dark cloud from NASA’s Spitzer Space Telescope. Called “Rho Oph” by astronomers, it’s one of the closest star-forming regions to our own solar system. Located near the constellations Scorpius and Ophiuchus, the nebula is about 407 light years away from Earth.

Rho Oph is a complex made up of a large main cloud of molecular hydrogen, a key molecule allowing new stars to form from cold cosmic gas, with two long streamers trailing off in different directions. Recent studies using the latest X-ray and infrared observations reveal more than 300 young stellar objects within the large central cloud. Their median age is only 300,000 years, very young compared to some of the universe’s oldest stars, which are more than 12 billion years old.

This false-color image of Rho Oph’s main cloud, Lynds 1688, was created with data from Spitzer’s infrared array camera, which has the highest spatial resolution of Spitzer’s three imaging instruments, and its multiband imaging photometer, best for detecting cooler materials. Blue represents 3.6-micron light; green shows light of 8 microns; and red is 24-micron light. The multiple wavelengths reveal different aspects of the dust surrounding and between the embedded stars, yielding information about the stars and their birthplace.

The colors in this image reflect the relative temperatures and evolutionary states of the various stars. The youngest stars are surrounded by dusty disks of gas from which they, and their potential planetary systems, are forming. These young disk systems show up as red in this image. Some of these young stellar objects are surrounded by their own compact nebulae. More evolved stars, which have shed their natal material, are blue.

The extended white nebula in the center right of the image is a region of the cloud which is glowing in infrared light due to the heating of dust by bright young stars near the right edge of the cloud. Fainter multi-hued diffuse emission fills the image. The color of the nebulosity depends on the temperature, composition and size of the dust grains. Most of the stars forming now are concentrated in a filament of cold, dense gas that shows up as a dark cloud in the lower center and left side of the image against the bright background of the warm dust. Although infrared radiation at 24 microns pierces through dust easily, this dark filament is incredibly opaque, appearing dark even at the longest wavelengths in the image.

Image and info via NASA: https://www.nasa.gov/feature/jpl/sixteen-images-for-spitzers-sweet-16

Source: https://myfusimotors.com/2019/12/27/young-stars-in-their-baby-blanket-of-dust/

Parkinson's disease may start before birth

People who develop Parkinson’s disease before age 50 may have been born with disordered brain cells that went undetected for decades, according to new Cedars-Sinai research. The research points to a drug that potentially might help correct these disease processes.

Parkinson’s occurs when brain neurons that make dopamine, a substance that helps coordinate muscle movement, become impaired or die. Symptoms, which get worse over time, include slowness of movement, rigid muscles, tremors and loss of balance. In most cases, the exact cause of neuron failure is unclear, and there is no known cure.

At least 500,000 people in the U.S. are diagnosed with Parkinson’s each year, and the incidence is rising. Although most patients are 60 or older when they are diagnosed, about 10% are between 21 and 50 years old. The new study, published in the journal Nature Medicine, focuses on these young-onset patients.

“Young-onset Parkinson’s is especially heartbreaking because it strikes people at the prime of life,” said Michele Tagliati, MD, director of the Movement Disorders Program, vice chair and professor in the Department of Neurology at Cedars-Sinai. “This exciting new research provides hope that one day we may be able to detect and take early action to prevent this disease in at-risk individuals.” Tagliati was a co-author of the study.

To perform the study, the research team generated special stem cells, known as induced pluripotent stem cells (iPSCs), from cells of patients with young-onset Parkinson’s disease. This process involves taking adult blood cells “back in time” to a primitive embryonic state. These iPSCs can then produce any cell type of the human body, all genetically identical to the patient’s own cells. The team used the iPSCs to produce dopamine neurons from each patient and then cultured them in a dish and analyzed the neurons’ functions.

“Our technique gave us a window back in time to see how well the dopamine neurons might have functioned from the very start of a patient’s life,” said Clive Svendsen, PhD, director of the Cedars-Sinai Board of Governors Regenerative Medicine Institute and professor of Biomedical Sciences and Medicine at Cedars-Sinai. He was the study’s senior author.

The researchers detected two key abnormalities in the dopamine neurons in the dish:

·         Accumulation of a protein called alpha-synuclein, which occurs in most forms of Parkinson’s disease.

·         Malfunctioning lysosomes, cell structures that act as “trash cans” for the cell to break down and dispose of proteins. This malfunction could cause alpha-synuclein to build up.

“What we are seeing using this new model are the very first signs of young-onset Parkinson’s,” said Svendsen. “It appears that dopamine neurons in these individuals may continue to mishandle alpha-synuclein over a period of 20 or 30 years, causing Parkinson’s symptoms to emerge.”

The investigators also used their iPSC model to test a number of drugs that might reverse the abnormalities they had observed. They found that that one drug, PEP005, which is already approved by the Food and Drug Administration for treating precancers of the skin, reduced the elevated levels of alpha-synuclein in both the dopamine neurons in the dish and in laboratory mice.

The drug also countered another abnormality they found in the patients’ dopamine neurons — elevated levels of an active version of an enzyme called protein kinase C — although the role of this enzyme version in Parkinson’s is not clear.

For the next steps, Tagliati said the team plans to investigate how PEP005, currently available in gel form, might be delivered to the brain to potentially treat or prevent young-onset Parkinson’s. The team also plans more research to determine whether the abnormalities the study found in neurons of young-onset Parkinson’s patients also exist in other forms of Parkinson’s.

“This research is an outstanding example of how physicians and investigators from different disciplines join forces to produce translational science with the potential to help patients,” said Shlomo Melmed, MB, ChB, executive vice president of Academic Affairs and dean of the Medical Faculty at Cedars-Sinai. “This important work is made possible by the dual leadership of Cedars-Sinai as both a distinguished academic institution and an outstanding hospital.”

Source: https://www.cedars-sinai.org/newsroom/parkinsons-disease-may-start-before-birth/

Journal article: https://www.nature.com/articles/s41591-019-0739-1

Source: https://myfusimotors.com/2020/01/28/parkinsons-disease-may-start-before-birth/