Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and aspirin are widely used to treat pain and inflammation. But even at similar doses, different NSAIDs can have unexpected and unexplained effects on many diseases, including heart disease and cancer.
Now, a new Yale-led study has uncovered
a previously unknown process by which some NSAIDs affect the body. The finding
may explain why similar NSAIDs produce a range of clinical outcomes and could
inform how the drugs are used in the future.
The study was published May 18 in the
journal Immunity.
Until now, the anti-inflammatory effects
of NSAIDs were believed to arise solely through the inhibition of certain
enzymes. But this mechanism does not account for many clinical outcomes that
vary across the family of drugs. For example, some NSAIDs prevent heart disease
while others cause it, some NSAIDs have been linked to decreased incidence of
colorectal cancer, and various NSAIDs can have a wide range of effects on
asthma.
Now, using cell cultures and mice, Yale
researchers have uncovered a distinct mechanism by which a subset of NSAIDs
reduce inflammation. And that mechanism may help explain some of these curious
effects.
The research showed that only some
NSAIDs — including indomethacin, which is used to treat arthritis and gout, and
ibuprofen — also activate a protein called nuclear factor erythroid 2-related
factor 2, or NRF2, which, among its many actions, triggers anti-inflammatory
processes in the body.
“It’s interesting and exciting that NSAIDs
have a different mode of action than what was known previously,” said Anna Eisenstein, an instructor at the Yale School of Medicine and lead author of the
study. “And because people use NSAIDs so frequently, it’s important we know
what they’re doing in the body.”
The research team can’t say for sure
that NSAIDs’ unexpected effects are due to NRF2 — that will require more
research. “But I think these findings are suggestive of that,” Eisenstein said.
Eisenstein is now looking into some of
the drugs’ dermatological effects — causing rashes, exacerbating hives, and
worsening allergies — and whether they are mediated by NRF2.
This discovery still needs to be
confirmed in humans, the researchers note. But if it is, the findings could
have impacts on how inflammation is treated and how NSAIDs are used.
For instance, several clinical trials
are evaluating whether NRF2-activating drugs are effective in treating
inflammatory diseases like Alzheimer’s disease, asthma, and various cancers;
this research could inform the potential and limitations of those drugs.
Additionally, NSAIDs might be more effectively prescribed going forward, with
NRF2-activating NSAIDs and non-NRF2-activating NSAIDs applied to the diseases
they’re most likely to treat.
The findings may also point to entirely
new applications for NSAIDs, said Eisenstein.
NRF2 controls a large number of genes
involved in a wide range of processes, including metabolism, immune response,
and inflammation. And the protein has been implicated in aging, longevity, and
cellular stress reduction.
Said Eisenstein, “That NRF2 does so much
suggests that NSAIDs might have other effects, whether beneficial or adverse,
that we haven’t yet looked for.”
Source: https://news.yale.edu/2022/05/18/new-research-may-explain-unexpected-effects-common-painkillers
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