Opioids are the most powerful painkillers. Researchers at the Charité – Universitätsmedizin Berlin have now found that the analgesic effects of opioids are not exclusively mediated by opioid receptors in the brain, but can also be mediated via the activation of receptors in immune cells. These findings represent a novel concept in our understanding of the mechanisms of opioid analgesia. Results from this research, published in the journal Brain, Behavior, and Immunity, show that pain reduction in mice was mediated by the activation of opioid receptors in immune cells.
PR:https://www.charite.de/en/service/press_reports/artikel/detail/opioids_produce_analgesia_via_immune_cells/
Journal article:https://www.nature.com/articles/srep32799
Corina Marinescu
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